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Vioxx
Pronounced: VYE-ox
Generic name: Rofecoxib
Vioxx is a new kind of painkiller used in the treatment of osteoarthritis, painful menstruation (dysmenorrhea), and other types of acute pain. It is part of a class of nonsteroidal anti-inflammatory drugs (NSAIDs) called "COX-2 inhibitors." Currently, the only other drug in this class is the new arthritis medication called Celebrex.
Like older NSAIDs such as aspirin, Motrin, and Naprosyn, Vioxx and Celebrex are believed to fight pain and inflammation by inhibiting the effect of a natural enzyme called COX-2. Unlike the older medications, however, these newer drugs do not interfere with a similar substance, called COX-1, which exerts a protective effect on the lining of the stomach. Vioxx and Celebrex are therefore less likely to cause the bleeding and ulcers that sometimes accompany sustained use of the older NSAIDs.
Although COX-2 inhibitors offer many of the same benefits as aspirin, they do not share its blood-thinning effects. If you're taking low-dose aspirin to reduce the risk of a heart attack, you'll need to continue taking it in addition to Vioxx.
ADULTS
Osteoarthritis
The usual starting dose is 12.5 milligrams once daily. The doctor may increase your dose to a maximum of 25 milligrams once daily if needed.
Acute Pain and Dysmenorrhea
The recommended dose is 50 milligrams once daily as needed, for no more than 5 days. |
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