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Isosorbide (ISDN)
Generic name: Isosorbide dinitrate
Other brand name: Isordil
Isosorbide dinitrate is prescribed to relieve or prevent angina pectoris (suffocating chest pain). Angina pectoris occurs when the arteries and veins become constricted and sufficient oxygen does not reach the heart. Isosorbide dinitrate dilates the blood vessels by relaxing the muscles in their walls. Oxygen flow improves as the vessels relax, and chest pain subsides.
In swallowed capsules or tablets, Isosorbide dinitrate helps to increase the amount of exercise you can do before chest pain begins.
In chewable or sublingual (held under the tongue) tablets, Isosorbide dinitrate can help relieve chest pain that has already started or prevent pain expected from a strenuous activity such as walking up a hill or climbing stairs.
ADULTS
The usual sublingual starting dose for the treatment of angina pectoris is 2.5 milligrams to 5 milligrams. Your doctor will increase this initial dose gradually until the pain subsides or side effects prove bothersome.
The usual sublingual starting dose for the prevention of an impending attack of angina pectoris is usually 5 or 10 milligrams every 2 to 3 hours.
To prevent chronic stable angina pectoris, the usual starting dose for swallowed, immediately released Isosorbide dinitrate is 5 to 20 milligrams. Your doctor may increase this initial dose to 10 to 40 milligrams every 6 hours.
To prevent chronic stable angina pectoris with controlled-release Isosorbide dinitrate the usual initial dose is 40 milligrams. Your doctor may increase this dose from 40 to 80 milligrams given every 8 to 12 hours. |
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